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Cetirizine
Clinical data
Pronunciation/ s ɛ ˈ t ɪr ɪ z iː n /
Trade namesZyrtec, Incidal, others
AHFS/Drugs.comMonograph
MedlinePlusa698026
License dataUS   FDA: Cetirizine
Pregnancy categoryAU: B2 US: B (No risk in non-human studies)
Routes of administrationBy mouth
ATC codeR06AE07 ( WHO )
Legal status
Legal statusAU: Unscheduled CA : OTC UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
BioavailabilityWell-absorbed (>70%) [3]
Protein binding88–96% [3]
MetabolismMinimal (non-cytochrome P450-mediated) [1] [2]
Onset of action20–42 minutes [2]
Elimination half-lifeMean: 8.3 hours [1] [2] Range: 6.5–10 hours [4]
Duration of action≥24 hours [4]
ExcretionUrine: 70–85% [1] Feces: 10–13% [1]

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