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Disulfiram
Clinical data
Trade namesAntabuse
AHFS/Drugs.comMonograph
MedlinePlusa682602
Pregnancy categoryUS: C (Risk not ruled out)
Routes of administrationOral, subdermal implant
ATC codeN07BB01 ( WHO ) P03AA04 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
MetabolismHepatic to diethylthiocarbamate
Elimination half-life60–120 hours

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On the other hand, acute alcohol ingestion appears to decrease warfarin's metabolism, which can greatly increase the risk for a hemorrhage. The exact mechanism is not well elucidated in the literature and may involve impaired hepatic metabolism as well as other patient-specific factors.When Antabuse is used as part of a treatment program for alcohol addiction or detoxification, your doctor may recommend that this medicine be given to you by a family member or other caregiver.

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Some drugs may have another patient information leaflet.The origins of Antabuse or Disulfiram have nothing to do with treating alcohol dependency.

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1 2 These effects are caused by accumulation of acetaldehyde, a major but toxic metabolite of alcohol formed by the enzyme alcohol dehydrogenase. 1 2 The reaction has been variously termed a disulfiram-like reaction, alcohol intolerance, and acetaldehyde syndrome.More generally, a patient survey will have to be designed to evaluate how many patients have benefited of DSF and how many have not, metoclopramide overdose.

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