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|Pronunciation||/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil|
|Trade names||Viagra, Revatio, others|
|License data||EU EMA: by INN, US FDA: Sildenafil|
|Pregnancy category||AU: B1 US: B (No risk in non-human studies)|
|Routes of administration||By mouth (tablets), IV|
|ATC code||G04BE03 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)|
|Bioavailability||41% (mean) |
|Metabolism||Liver: CYP3A4 (major route), CYP2C9 (minor route)|
|Metabolites||N -desmethylsildenafil (~50% potency for PDE 5 )|
|Elimination half-life||3–4 hours|
|Excretion||Feces (~80%), urine (~13%) |
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N11-716. Montorsi F, McDermott TED, Morgan R, Olsson A, Schultz A, Kirkeby HJ, Osterloh IH "Efficacy and safety of fixed-dose oral sildenafil in the treatment of erectile dysfunction of various etiologies.Abstracts, buys sildenafil 20 mg and articles that did not contain accurate relevant data and a comparative analysis of sildenafil and tadalafil were excluded.
Two independent reviewers evaluated all identified publications, and any disagreement between reviewers was resolved by a third reviewer.
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REVATIO injection is supplied as a how to order sildenafil, colorless, sterile, ready to use solution containing 10 mg sildenafil/12.-fold increase in sildenafil plasma AUC.
At 24 hours, the plasma levels of sildenafil were still approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was administered alone. his is consistent with ritonavir's marked effects on a broad range of P450 substrates.
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Decrease in sildenafil AUC and Cmax, respectively.Dose adjustments are not required in elderly patients. Clinical efficacy as measured by 6-minute walk distance could be less in elderly patients.
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