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Vytorin properties
Drug name Vytorin
Vytorin all other nameacotral, afordel, alcosin, alipas, alpheus, angiolip, antichol, arudel, astax, aterostat, athenil, atorvik-ez, avastin, awestatin, belmalip, bevostatin, cardin, cerclerol, cholemed, cholestad, cholestat, cholipam, christatin, colemin, colemin forte, colesken, colestop, colestricon, coracil, corexel, corsim, covastin, cynt, detrovel, ecuvas, egilipid, esvat, ethicol, extrastatin, ezentia, ezeta, ezetib, ezetim, ezetimib, ezetimibum, ezitoget, forcad, gerosim, glipal, glutasey, goldastatin, goltor, histop, hollesta, iamastatin, ifistatin, inegan, inegy, ipramid, ivast, ixacor, jabastatina, kavelor, klonastin, krustat, kymazol, labistatin, lepur, lesvatin, lip-down, lipcut, lipenil, lipexal, lipidex, lipo-off, lipoaut, lipoblock, lipociden, lipodown, lipokoban, lipola m, lipomed, lipopress, liporex, lipovatol, lipozart, lipozid, lisac, lowcholid, lumsiva, medipo, medistatin, mersivas, michol, nalecol, nezatin, nimicor, nitastin, nivelipol, normicor, normofat, nosterol, novastin, nyzoc, omistat, pantok, pantok forte, phalol, pontizoc, protecta, pulsarat, ramian, ransim, rechol, recol, redicor, redulip, redusterol, rendapid, ritec
Active substanceezetimibe, simvastatin
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    HrExcretion: Feces 60% urine 13% Bioavailability: VariablePeak plasma time: 4-12 hrExcretioin: Feces 78% urine 11% Half-life: 22 hrMetabolism: Undergoes glucuronide conjugation in the vytorin generic launch intestine and liver SLCO1B1 OATP1B1 CC genotype significantly increases AUCs of parent drug and metabolites compared with the CT or TT genotypes This polymorphism is proposed to reduced vytorin generic launch into the liver, the main site of statin metabolism and elimination, resulting in elevated plasma concentrations SLCO1B1 polymorphism is thought to have a vytorin generic launch effect on the more hydrophilic statins eg, rosuvastatin, fluvastatin compared with more those that are more lipophilic eg, atorvastatin, pravastatin, simvastatin Other genetic polymorphisms of elimination eg, CYP450, P-glycoprotein for each individual drug must also be considered to explain variability for statin clearance among patients that exhibit SCLO1B1 polymorphism SLCO1B1 CC genotype is most common in Caucasians and Asians 15% Risk of myopathy is 2.

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