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|Pronunciation||/ ˈ aɪ b juː p r oʊ f ɛ n /, / aɪ b juː ˈ p r oʊ f ən /, EYE -bew- PROH -fən|
|Trade names||Advil, Motrin, Nurofen, others|
|License data||EU EMA: by INN, US FDA: Ibuprofen|
|Pregnancy category||AU: C US: C (Risk not ruled out) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus|
|Routes of administration||by mouth, rectal, topical, and intravenous|
|ATC code||C01EB16 ( WHO ) G02CC01 ( WHO ) M01AE01 ( WHO ) M02AA13 ( WHO ) R02AX02 ( WHO )|
|Legal status||AU: OTC CA : OTC UK: General sales list (GSL, OTC) US: OTC (R x -only at higher doses)|
|Bioavailability||80–100% (by mouth),  87% (rectal)|
|Protein binding||98% |
|Metabolism||Liver (CYP2C9) |
|Metabolites||ibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen|
|Onset of action||30 min |
|Elimination half-life||2–4 h |
|Excretion||Urine (95%)  |
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or example, inhibition of PGE2 production may reduce hyperalgesia but may also reduce the tissue-protective effects of this prostanoid in various organs, including the gastrointestinal tract, vascular wall, kidney, and lung.
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