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Domperidone
Clinical data
Trade namesMotilium, many others
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy categoryAU: B2 US: N (Not classified yet)
Routes of administrationBy mouth, intramuscular, intravenous (d/c'd), rectal [1]
Drug classD 2 receptor antagonist; Prolactin releaser
ATC codeA03FA03 ( WHO ) QP51AX24 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: Not approved for use or sale, Prescription medicine (Rx only):Pakistan, India, Australia, Canada, Israel, Belgium, France, Netherlands; over-the-counter: Egypt, Ireland, Italy, Japan, South Africa, Switzerland, China, Russia, Slovakia, Ukraine [2] Mexico, Thailand, Malta, South Korea, and Romania [3]
Pharmacokinetic data
BioavailabilityOral: 13–17% [1] [5] Intramuscular: 90% [1]
Protein binding~92% [1]
MetabolismHepatic (CYP3A4/5) and intestinal (first-pass) [1] [4]
MetabolitesAll inactive [1] [4]
Elimination half-life7.5 hours [1] [5]
ExcretionFeces: 66% [1] Urine: 32% [1] Breast milk: small quantities [1]

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Harefuah. 1982 Apr 15;102(8):356-7. [Domperidone ( Motilium )]. [Article in Hebrew]. Tauber A, Eschar J. PMID: 7117983; [Indexed for MEDLINE]. Publication ...

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