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Intrathecal baclofen acts on the central nervous system CNS to produce its muscle relaxant effects.until the steady state is achieved Adult Patients with Spasticity of Spinal Cord Origin: After the baclofen a narcotic 24 hours, for baclofen a narcotic patients, the daily dosage should be increased slowly by 10-30% increments and only once every 24 hours, until the desired clinical effect is achieved. Adult Patients with Spasticity of Cerebral Origin: After the first 24 hours, the daily dose should be increased slowly by 5-15% only once every 24 hours, until the desired clinical effect is achieved.

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Copyright 2019 de Beaurepaire, Sinclair, Heydtmann, Addolorato, Aubin, Beraha, Caputo, Chick, de La Selle, Franchitto, Garbutt, Haber, Jaury, Lingford-Hughes, Morley, M ller, Owens, Pastor, Paterson, P lissier, Rolland, Stafford, Thompson, van den Brink, Leggio and Agabio.

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Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia an evidence-based review report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies.


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