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|Trade names||Prometrium, Utrogestan, Endometrin, Crinone, others|
|Pregnancy category||B (US)|
|Routes of administration||• By mouth (capsule) • Sublingual (tablet) • Topical (cream, gel) • Vaginal (capsule, tablet, gel, suppository, ring) • Rectal (suppository) • IM injection (oil solution) • SC injection (aq. soln.) • Intrauterine (IUD)|
|Drug class||Progestogen; Antimineralocorticoid; Neurosteroid|
|ATC code||G03DA04 ( WHO )|
|Legal status||In general: ℞ (Prescription only)|
|Bioavailability||Oral: <2.4%  Vaginal: 4–8%   |
|Protein binding||98–99%:   • Albumin: 80% • CBG: 18% • SHBG: <1% • Free: 1–2%|
|Metabolism||Mainly liver: • 5α- and 5β-reductase • 3α- and 3β-HSD • 20α- and 20β-HSD • Conjugation • 17α-Hydroxylase • 21-Hydroxylase • CYPs (e.g., CYP3A4)|
|Metabolites||• Dihydroprogesterones • Pregnanolones • Pregnanediols • 20α-Hydroxyprogesterone • 17α-Hydroxyprogesterone • Pregnanetriols • 11-Deoxycorticosterone (And glucuronide/sulfate conjugates)|
|Elimination half-life||• Oral: 5 hours (with food)  * Sublingual: 6–7 hours  • Vaginal: 14–50 hours   • Topical: 30–40 hours  • IM: 20–28 hours    • SC: 13–18 hours  • IV: 3–90 minutes |
|Excretion||Bile and urine  |
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The treating naturopath or anti-aging physician should measure progesterone and estrogen levels in a saliva hormone test.
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2013; Toffoletto et al.Brighouse D. Hormone replacement therapy HRT and anaesthesia.
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Oi.Around one third of the women who received micronized progesterone had amenorrhea after 6 and 18 months. Overall bleeding status was more stable with progesterone than with chlormadinone acetate Fig.
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Delivered sweet baby boy at 34 weeks, vaginally.This is the most significant issue for the majority of women; many of the early symptoms that women feel are due to progesterone levels that are too low, in relation to their levels of estrogen.
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US orders progesterone cream online can call their local poison control center at 1-800-222-1222.For a long time, however, the established opinion was that oral administration of progesterone had only limited efficacy, as its bioavailability was strongly reduced due to the hepatic first-pass effect 12.
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