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The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics including barbiturates narcotics, narcotic analgesics, general promethazine inj, tricyclic antidepressants, promethazine inj tranquilizers; therefore such agents should either be eliminated or given promethazine inj reduced dosage in the presence of promethazine HCl see PRECAUTIONS-Information for Patients and Drug Interactions Promethazine may lower seizure threshold.
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O 0United States National Library of Medicine "Toxnet. Toxicology Data Network.IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HYDROCHLORIDE BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE Promethazine inj.
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