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children may be particularly sensitive to additive respiratory depressant effects when promethazine is combined with other respiratory depressants, including codeine Risks from concomitant use with benzodiazepines or promethazine shirt CNS depressants; concomitant use of opioids with benzodiazepines or other central nervous system CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death; eserve concomitant prescribing of this drug combination and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate; imit dosages and durations to minimum required; promethazine shirt patients for signs and symptoms of respiratory promethazine shirt and sedationAddiction, abuse, and misuse; life-threatening respiratory depression; accidental ingestion; risks from concomitant use with benzodiazepines or other CNS depressants; ultra- rapid metabolism of codeine and promethazine shirt risk factors for life-threatening respiratory depression in children; neonatal opioid withdrawal syndrome; promethazine shirts with drugs affecting cytochrome p450 promethazine shirts and hepatotoxicity Deaths have occurred in promethazine shirts with obstructive sleep apnea who receive codeine for postoperative pain following tonsillectomy and/or adenoidectomyContraindicated in children 18 promethazine shirts following tonsillectomy and/or adenoidectomy; avoid use in adolescents 12-18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine; odeine is converted to promethazine shirt by promethazine vc with codeine promethazine shirt these children had promethazine shirt of being ultra-rapid metabolizers via CYP2D6 of codeine, which is an inherited genetic ability that causes codeine to be converted rapidly into life-threatening or fatal amounts of morphine see Pharmacology oncomitant use of opioids with benzodiazepines or other central nervous system CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death; avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol 12 years risk of potentially fatal respiratory depression ubcutaneous or intra-arterially administrationBenign prostatic hypertrophyNarrow angle glaucomaPyloroduodenal obstruction, stenosing peptic ulcer, bladder neck obstructionSevere CNS depressionComa, severe respiratory depression Absolute: acute abdominal condition, diarrhea associated w/ toxins, pseudomembranous colitis, respiratory depressionRelative: promethazine shirt acute inflammatory bowel disease, respiratory impairmentChildren 18 years following tonsillectomy and/or adenoidectomyAcute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipmentConcurrent use of monoamine oxidase inhibitors MAOIs or use of MAOIs within the last14 daysSignificant respiratory depressionPorphyriaTreatment of lower respiratory tract symptoms, including asthmaKnown or suspected gastrointestinal obstruction, including paralytic ileus Concomitant use of opioids, including promethazine HCl and codeine phosphate oral solution, with benzodiazepines, or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death; because of these risks, avoid use of opioid promethazine shirt medications in patients taking benzodiazepines, other CNS depressants, or alcohol Caution in CVD, promethazine shirt, hepatic impairment, peptic ulcer, respiratory impairment; the impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics including barbiturates narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; avoid use of promethazine HCl and codeine phosphate oral solution in patients on these medicationsAnaphylaxis in susceptible individualsMay impair ability to drive or perform hazardous tasksMonitor closely with cardiovascular promethazine shirt, hepatic impairment, Reye syndrome, history of sleep apneaDepresses hypothalamic thermoregulatory mechanism; exposure to extreme temperatures may cause hypo- or hyperthermiaAntiemetic effect may obscure toxicity of chemotherapeutic drugsConcomitant use of opioids, including promethazine HCl and codeine phosphate promethazine shirt solution, with benzodiazepines, or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death; avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcoholConvulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients; promethazine may lower seizure threshold; it should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure thresholdPromethazine is a phenothiazine; phenothiazines are associated with dystonic reactions; in pediatric patients who are acutely ill associated with dehydration, there is increased susceptibility to dystonias with promethazine HCl useThe respiratory-depressant effects of narcotic analgesics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in presence of head injury, intracranial lesions, or a pre-existing increase in intracranial pressure; narcotics may produce adverse reactions which may obscure clinical promethazine shirt of promethazine shirts with head injuriesA potentially fatal promethazine shirt complex sometimes referred to as Neuroleptic Malignant Syndrome NMS reported in promethazine shirt with promethazine HCl alone or in combination with antipsychotic drugs; 1 management of NMS should include immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not promethazine shirt to promethazine shirt therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are availablePromethazine should be used promethazine shirt caution in promethazine shirts with bone-marrow depression; leukopenia and agranulocytosis reported, usually when promethazine HCl has been used in association with other known marrow-toxic agents Caution in cardiac arrhythmias, drug abuse/dependence, emotional lability, gallbladder disease, head injury, hepatic impairment, hypothyroidism, increased ICP, prostatic hypertrophy, renal impairment, seizures w/ epilepsy, urethral stricture, urinary tract surgeryRisk of life threatening side effects in nursing babies, especially if mother is an ultra rapid metabolizer of codeineCodeine is subject to variability in metabolism based upon CYP2D6 genotype described below which can lead to an increased exposure to the active metabolite morphineAvoid use of capsules in adolescents 12-18 years of age who have other risk factors that may increase promethazine shirt to respiratory promethazine shirt effects of codeine unless outweigh risks; risk factors include conditions associated with hypoventilation, such as postoperative status, obstructive sleep apnea, obesity, severe pulmonary disease, neuromuscular disease, and concomitant use of other medications that cause respiratory depression; when prescribing codeine for adolescents, healthcare promethazine shirts should choose lowest effective dose for shortest period of time and inform patients and caregivers about promethazine shirts and the signs of morphine overdoseDosage of codeine should not be increased if cough fails to respond; an unresponsive coughshould be reevaluated in 5 days or sooner for possible underlying pathology, such as foreignbody or lower respiratory tract diseaseNarcotic analgesics or cough suppressants, including codeine, should not be used in patients with severe asthma or those with frequent asthma attacksCodeine may produce orthostatic hypotension in ambulatory patientsCodeine may cause or aggravate constipationIbuprofen is more effective than codeine for pain from musculoskeletal injuries in children Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome; available data in pregnant women are insufficient to inform a drug-associated risk for major birth defects and miscarriage Use of codeine during labor may lead to respiratory depression in the neonate; pioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates; an opioid antagonist, such as naloxone, promethazine shirt be available for reversal of opioid-induced respiratory depression in the neonate; use is not recommended in pregnant women during or immediately promethazine shirt to labor, when other analgesic techniques are more appropriate; opioid promethazine shirts, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions; however, this promethazine shirt is not consistent and may be offset by increased rate of cervical dilation, which tends to shorten labor; monitor neonates exposed to opioid analgesics during labor for signs of promethazine shirt sedation and respiratory depression Codeine and its active metabolite, morphine, are present in human milk; there are published studies and cases that have reported excessive sedation, respiratory depression, and death in infants exposed to codeine via breast milk; women who are ultra-rapid metabolizers of codeine achieve higher than expected serum levels of morphine, potentially leading to higher levels of morphine in breast milk that can be dangerous in their breastfed infants; in women with normal codeine metabolism normal CYP2D6 activity the amount of codeine secreted into human milk is low and dose-dependent; at least one death was reported in a nursing infant who was exposed to high levels of morphine in breast milk because mother was an ultra-rapid metabolizer of codeine; breastfeeding not recommended There is no information on effects of codeine milk production; because of potential for serious adverse reactions, including excess sedation, respiratory depression, and death in a breastfed infant, breastfeeding is not recommended during treatmentA: Generally acceptable.

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To 25 mg twice daily, may be administered. Antiemetics should not be used in vomiting of promethazine shirt etiology in children and adolescents see WARNINGS-Use in Pediatric Patients The average effective dose of promethazine hydrochloride for the promethazine shirt therapy of nausea and vomiting in children or adults is 25 mg.ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTS, AND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGY.


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In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.Acidosis and electrolyte losses should be corrected.

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Many promethazine shirt using this medication do not have serious side effects.Do not take double or extra doses. This list may not describe all possible interactions.


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