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Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Sildenafil doe sildenafil delay ejaculation the name Viagra is connected to treat erectile dysfunction impotence in men. Recreational use of sildenafil is Revatio, which is determined to overdose pulmonary arterial hypertension and leg exercise capacity in men and airways. Do not take sildenafil if you are also using a paste drug for chest pain or perform many.

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Headache was the most common adverse effect reported in controlled clinical trials with sildenafil, occurring in 16% of does sildenafil delay ejaculation with ED and 46% of patients with PAH, and may be severe enough to result in discontinuance of the drug; migraine occurred in less than 2% of patients.

Headache probably results from the vasodilatory effects of sildenafil, but it remains to be established whether tolerance to this effect develops with continued use.of patients.

In another clinical trial in does sildenafil delay ejaculation with impotence as a result of complications of diabetes mellitus completing the recommended dose titration, no patients opted to decrease the dose to 25 mg from sildenafil brasil or 100 mg; at the end of the 12-week study, 93% of patients were receiving the 100-mg dose and 7% were receiving the 50-mg dose.

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