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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant medication on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants thiazide and related diuretics, sildenafil buy and potassium sparing diuretics, angiotensin sildenafil buying enzyme inhibitors, calcium sildenafil buy blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism such as rifampicin, barbiturates In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4moderate, CYP2C9 and possibly of CYP2C19 at steady state 125 mg twice a day sildenafil buy sildenafil at steady state 80 mg three times a day resulted in 62.Because information concerning persistent or unexpected vision abnormalities reported with sildenafil use is limited, patients should be advised to remain alert for the possibility of such changes.

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The use of prostacyclin analogues, endothelin receptor antagonists, and arginine supplementation were not permitted. Subjects who had failed to respond to bosentan were also excluded.The sildenafil tablet for sale and efficacy of sildenafil for the treatment of PAH in children below 1 year of age has not been established as no data is available 15.

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In flexible-dose clinical studies in patients with erectile dysfunction ED 62% of all reported adverse effects were classified as mild, with only about 7% purchase sildenafil classified as severe. The most common adverse effects of sildenafil purchase sildenafil from the pharmacologic activity of the drug as a phosphodiesterase PDE inhibitor, including those secondary to vascular purchase sildenafil muscle relaxation and vasodilation from PDE type 5 inhibition, those secondary to relaxation of the lower esophageal sphincter from PDE type 5 inhibition, those secondary to mucosal hyperemia from PDE type 5 inhibition, and those secondary to ocular PDE type 6 inhibition.See the end of this leaflet for a complete list of ingredients in Viagra.

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