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Doxepin
Clinical data
Trade namesSinequan, Quitaxon, Aponal, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa682390
License dataUS   FDA: Doxepin
Pregnancy categoryAU: C US: B (No risk in non-human studies)
Routes of administrationBy mouth, topical, intravenous, intramuscular injection [1]
Drug classTricyclic antidepressant (TCA)
ATC codeD04AX01 ( WHO ) N06AA12 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability13–45% (mean 29%) [5] [6]
Protein binding76% [7]
MetabolismHepatic (CYP2D6, CYP2C19) [4] [5]
MetabolitesNordoxepin, glucuronide conjugates [4]
Elimination half-lifeDoxepin: 8–24 hours (mean 17 hours) [7] Nordoxepin: 31 hours [7]
ExcretionUrine: ~50% [4] [5] Feces: minor [5]

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Doxepin information
Tablet name Doxepin
Doxepin all other nameadapin, anten, aponal, deptran, doneurin, doxal, doxépine, doxepini, doxepinum, doxin, espadox, expan, gilex, ichderm, mareen, quitaxon, sagalon, silenor, sinepin, sinquan, spectra, triadapin, xepin, zonalon
Active substancessinequan
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