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Diclofenac
Clinical data
Trade namesCataflam, Voltaren, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa689002
Pregnancy categoryAU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester
Routes of administrationBy mouth, rectal, intramuscular, intravenous (renal- and gallstones), topical
ATC codeD11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures
Pharmacokinetic data
Protein bindingMore than 99%
MetabolismLiver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; [2] no active metabolites exist
Elimination half-life1.2–2 hr (35% of the drug enters enterohepatic recirculation)
Excretion40% biliary 60% urine

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BIG MISTAKE ON MY PART! Following the formulations of diclofenac I applied a pea-sized amount in a very small area.Blood and urine tests may be needed to check for unwanted effects.

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Voriconazole: When co-administered with voriconazole inhibitor of CYP2C9, 2C19 and 3A4 enzyme the Cmax and AUC of diclofenac increased by 114% and 78% respectively see DRUG INTERACTIONS Aspirin: When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered.

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US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.Step 3.

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