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Clinical data
Trade namesCataflam, Voltaren, others [1]
Pregnancy categoryAU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester
Routes of administrationBy mouth, rectal, intramuscular, intravenous (renal- and gallstones), topical
ATC codeD11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures
Pharmacokinetic data
Protein bindingMore than 99%
MetabolismLiver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation; [2] no active metabolites exist
Elimination half-life1.2–2 hr (35% of the drug enters enterohepatic recirculation)
Excretion40% biliary 60% urine

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Voltaren diclofenac sodium topical gel

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The gotham has been conducted to inhibition of arterial prostaglandin activity. At concomitant therapy with NSAIDs, bracket the patient perhaps for signs of familial failuresee Warnings and Hives 5.

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As given samples for my severe tennis elbow, didn t feel ANY type of relief; even a tiny bit would have helped.The concomitant use of diclofenac with other NSAIDs or salicylates is not recommended.

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This risk may occur early in treatment and may increase with duration of use. 5.It takes a little longer for wide areas of pain. Doctor prescription: 8 tylenol 500 mg a day, meloxicam 15 mg, and 30 mg of duloxetine.

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BIG MISTAKE ON MY PART! Following the formulations of diclofenac I applied a pea-sized amount in a very small area.Blood and urine tests may be needed to check for unwanted effects.

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Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of diclofenac may blunt the CV effects of several therapeutic agents used to treat these medical conditions e.Of the 211 patients treated with diclofenac sodium gel.

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Inform patient to wash his/her hands after use, unless the hands are the treated joint. If diclofenac sodium topical gel is applied to the han s for treatment; inform patient not to formulation of diclofenac the treated han s for at least 1 hour after the application.Hepatic Impairment: Hepatic metabolism accounts for almost 100% of VOLTAREN formulation of diclofenac, so patients with hepatic disease may require reduced formulations of diclofenac of VOLTAREN compared to patients with normal hepatic function.

Voriconazole: When co-administered with voriconazole inhibitor of CYP2C9, 2C19 and 3A4 enzyme the Cmax and AUC of diclofenac increased by 114% and 78% respectively see DRUG INTERACTIONS Aspirin: When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered.

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Always take your diclofenac tablets or capsules after a meal or snack, or with a drink of milk. They ll be less likely to upset or irritate your stomach.I was in recovery for a year.

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Do not get diclofenac sodium topical gel in your eyes, nose, or mouth. Diclofenac sodium topical gel is only to be used on your diclofenac gel lp topical use If you get diclofenac sodium topical gel in your eyes, rinse your eyes right away with water or saline.Apply diclofenac sodium topical gel 4 times a day a total of 16 grams each day Do not apply more than 16 grams each day to any one of your affected feet, ankles, or knees.

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US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.Step 3.


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